Xiaoxi Zhuang, PhD

We investigate the molecular machinery underlying synaptic plasticity and information processing in the brain. We are especially interested in synaptic mechanisms supporting reinforcement learning, economic decision making and motor control. Our main approaches include mouse genetics, fly genetics, optogenetics, animal learning paradigms, electrophysiology, molecular biology and RNA-seq.

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Xu H, Dzhashiashvili Y, Shah A, Kunjamma RB, Weng YL, Elbaz B, Fei Q, Jones JS, Li YI, Zhuang X, Ming GL, He C, Popko B. m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron. 2020 01 22; 105(2):293-309.e5.
PMID: 31901304

Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster.
Chi W, Iyengar ASR, Albersen M, Bosma M, Verhoeven-Duif NM, Wu CF, Zhuang X. Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster. Hum Mol Genet. 2019 09 15; 28(18):3126-3136.
PMID: 31261385

m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T. m6A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature. 2018 11; 563(7730):249-253.
PMID: 30401835

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, Zhuang X. Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning. Neuron. 2018 07 25; 99(2):283-292.e5.
PMID: 30056831

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.
Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Kr├╝ger R, Surmeier DJ, Krainc D. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science. 2017 09 22; 357(6357):1255-1261.
PMID: 28882997

Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster.
Lee YCG, Yang Q, Chi W, Turkson SA, Du WA, Kemkemer C, Zeng ZB, Long M, Zhuang X. Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster. Genome Biol Evol. 2017 05 01; 9(5):1357-1369.
PMID: 28472322

Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency.
Koranda JL, Krok AC, Xu J, Contractor A, McGehee DS, Beeler JA, Zhuang X. Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency. J Neurosci. 2016 05 11; 36(19):5228-40.
PMID: 27170121

Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation.
Beeler JA, Faust RP, Turkson S, Ye H, Zhuang X. Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation. Biol Psychiatry. 2016 06 01; 79(11):887-97.
PMID: 26281715

A53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.
Chen L, Xie Z, Turkson S, Zhuang X. A53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci. 2015 Jan 21; 35(3):890-905.
PMID: 25609609

Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons.
Augustin SM, Beeler JA, McGehee DS, Zhuang X. Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons. J Neurosci. 2014 May 07; 34(19):6692-9.
PMID: 24806695

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