Comparative investigation of human neural development
We aim to understand how the distinctive features of the human central nervous system emerge during development. By comparing human, non-human primate and rodent neural development, we systematically dissect the genetic mechanisms that confer the human CNS with its unique properties. Our research utilizes a wide range of computational and experimental approaches, centered around stem cell-derived organoids and single-cell genomics.
Columbia University
New York, NY
Postdoc - Neurodevelopment
2025
Harvard University
Cambridge, MA
PhD - Systems biology
2017
Independent control of neurogenesis and dorsoventral patterning by NKX2-2.
Independent control of neurogenesis and dorsoventral patterning by NKX2-2. Genes Dev. 2026 Mar 02; 40(5-6):384-395.
PMID: 41526180
A human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production.
A human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production. Nat Neurosci. 2024 Oct; 27(10):1945-1953.
PMID: 39210067
Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.
Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro. Nat Commun. 2022 09 15; 13(1):5427.
PMID: 36109497
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity.
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity. Neuron. 2022 01 05; 110(1):70-85.e6.
PMID: 34727520
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states.
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. Elife. 2017 03 15; 6.
PMID: 28296635
Fixed single-cell transcriptomic characterization of human radial glial diversity.
Fixed single-cell transcriptomic characterization of human radial glial diversity. Nat Methods. 2016 Jan; 13(1):87-93.
PMID: 26524239