The research in the laboratory is directed at issues of thalamic functional organization and thalamocortical relationships, mainly using the visual and somatosensory pathways in the mouse as experimental models. We use a broad interdisciplinary approach, attempting to answer the same or closely related questions with several different techniques. More specifically, we use neuroanatomical techniques to explore various circuits; we use in vitro recordings from brain slices to study cell and synaptic properties; and we record from in vivo preparations to evaluate these circuits in whole animals using an awake, behaving preparation to determine the relationship between behavioral and cognitive parameters and thalamocortical functioning.
Stimulation techniques in slices include electrical activation and laser photostimulation involving both uncaging of glutamate (or GABA) and optogenetics; recording involves mainly patching of single neurons and imaging via flavoprotein autofluorescence. For in vivo recording, we use conventional single cell electrophysiology, current source density analysis, and have recently imported the technique of 2-photon calcium imaging, which enables us to follow responses of hundreds of cortical cells simultaneously. To activate or inhibit specific pathways we use optogenetics and DREAD (Designer Receptors Exclusively Activated by Designer Drugs) techniques often involving specific mouse genetic lines (e.g., involving Cre expression in transgenic mouse lines)
M.A. (Honorary) - Neuroscience
Australian National University
NA - Postdoctoral training in neurophysiology
University of Pennsylvania
Ph.D. - Neuroanatomy
California Institute of Technology
B.S. - Biology
Layer 5 Corticofugal Projections from Diverse Cortical Areas: Variations on a Pattern of Thalamic and Extrathalamic Targets.
Prasad JA, Carroll BJ, Sherman SM. Layer 5 Corticofugal Projections from Diverse Cortical Areas: Variations on a Pattern of Thalamic and Extrathalamic Targets. J Neurosci. 2020 Jul 22; 40(30):5785-5796.
Thalamocortical Circuit Motifs: A General Framework.
Halassa MM, Sherman SM. Thalamocortical Circuit Motifs: A General Framework. Neuron. 2019 09 04; 103(5):762-770.
Convergent synaptic inputs to layer 1 cells of mouse cortex.
Lam YW, Sherman SM. Convergent synaptic inputs to layer 1 cells of mouse cortex. Eur J Neurosci. 2019 06; 49(11):1388-1399.
A Sensorimotor Pathway via Higher-Order Thalamus.
Mo C, Sherman SM. A Sensorimotor Pathway via Higher-Order Thalamus. J Neurosci. 2019 01 23; 39(4):692-704.
My prolonged collaboration with Ray Guillery.
Sherman SM. My prolonged collaboration with Ray Guillery. Eur J Neurosci. 2019 04; 49(7):928-937.
Corticofugal circuits: Communication lines from the cortex to the rest of the brain.
Usrey WM, Sherman SM. Corticofugal circuits: Communication lines from the cortex to the rest of the brain. J Comp Neurol. 2019 02 15; 527(3):640-650.
Rainer (Ray) W. Guillery 28 August 1929-7 April 2017.
Sherman SM, Mason CA, Atabay KD, Kaas JH, LaMantia AS, Mitchell A, Walsh C. Rainer (Ray) W. Guillery 28 August 1929-7 April 2017. Eur J Neurosci. 2017 08; 46(3):1933-1936.
Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus.
Mo C, Petrof I, Viaene AN, Sherman SM. Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6212-E6221.
Functioning of Circuits Connecting Thalamus and Cortex.
Sherman SM. Functioning of Circuits Connecting Thalamus and Cortex. Compr Physiol. 2017 03 16; 7(2):713-739.
Neuroscience Training for the 21st Century.
Akil H, Balice-Gordon R, Cardozo DL, Koroshetz W, Posey Norris SM, Sherer T, Sherman SM, Thiels E. Neuroscience Training for the 21st Century. Neuron. 2016 06 01; 90(5):917-26.
St. John’s College of Oxford University
2010 - 2010
2000 - 2001
Dr. Lee Visiting Research Fellow
of Christ Church College of University of Oxford
2000 - 2001
University of Science and Technology of China (Hefei
1998 - 2000
Newton Abraham Visiting Professor
Lincoln College of Oxford University
1985 - 1986
Honorary M.A. degree
1985 - 1985