We study mechanosensory signaling by the inner ear. We focus on the mouse utricle, where we have access to mechanosensitive receptor cells and primary afferent neurons. In this simple circuit we can address fundamental neurobiological questions, such as mechanotransduction, the nature of a simple sensory map, how transmission occurs across unique calyceal synapses, and how different kinds of information are encoded in the spike rate and timing of primary afferent neurons.
Caltech
Pasadena CA
PhD - Biology
McGill University
Montreal
B.Sc. - Honours Neurobiology
McGill University
Montreal
M.Sc. - Biology
MIT & Harvard
Cambridge, Boston
- Auditory Physiology
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons. bioRxiv. 2023 Nov 29.
PMID: 38076890
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells. bioRxiv. 2023 Nov 21.
PMID: 38045305
The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.
The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell. J Assoc Res Otolaryngol. 2023 04; 24(2):117-127.
PMID: 36648734
Nonquantal transmission at the vestibular hair cell-calyx synapse: KLV currents modulate fast electrical and slow K+ potentials.
Nonquantal transmission at the vestibular hair cell-calyx synapse: KLV currents modulate fast electrical and slow K+ potentials. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2207466120.
PMID: 36595693
The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse.
The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse. J Neurosci. 2021 09 15; 41(37):7779-7796.
PMID: 34301830
Predictors of pressure injury development in critically ill adults: A retrospective cohort study.
Sala JJ, Mayampurath A, Solmos S, Vonderheid SC, Banas M, D'Souza A, LaFond C. Predictors of pressure injury development in critically ill adults: A retrospective cohort study. Intensive Crit Care Nurs. 2021 Feb; 62:102924.
PMID: 12826658
Predictors of pressure injury development in critically ill adults: A retrospective cohort study.
Sala JJ, Mayampurath A, Solmos S, Vonderheid SC, Banas M, D'Souza A, LaFond C. Predictors of pressure injury development in critically ill adults: A retrospective cohort study. Intensive Crit Care Nurs. 2021 Feb; 62:102924.
PMID: 8694485
Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations.
Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations. Nat Commun. 2020 01 02; 11(1):63.
PMID: 31896743
Specializations for Fast Signaling in the Amniote Vestibular Inner Ear.
Eatock RA. Specializations for Fast Signaling in the Amniote Vestibular Inner Ear. . 2018 08 01; 58(2):341-350.
PMID: 29920589
Specializations for Fast Signaling in the Amniote Vestibular Inner Ear.
Specializations for Fast Signaling in the Amniote Vestibular Inner Ear. Integr Comp Biol. 2018 08 01; 58(2):341-350.
PMID: 29920589