Paschalis Kratsios, PhD

  • Assistant Professor of Neurobiology
  • Research and Scholarly Interests: C.elegans genetics, chromatin factors, gene regulation, Gene Regulatory Networks, mouse genetics, neuronal development, Transcription Factors
  • Websites: Kratsios Lab, Research Network Profile
  • Contact: pkratsios@uchicago.edu

My lab uses the specific strengths of two model systems (C.elegans and mice) to reveal the gene regulatory mechanisms that control motor neuron development and function. To reveal such mechanisms we employ novel methodology, such as whole genome sequencing, CRISPR genome editing, ATAC-seq and cell type-specific transcriptome profiling. Our laboratory aims to systematically test whether the function of the gene regulatory factors we discover in C.elegans is conserved across phylogeny using mouse genetics and novel genomic approaches.



A detailed understanding of how the motor neurons develop and function may provide novel entry points into the etiology, diagnosis or treatment of motor neuron disorders, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). From the basic science perspective, our research will reveal novel transcription factors, their targets and the cis-regulatory elements (motifs) through which these factors act. Such decoding of cis-regulatory information is a vital step toward understanding genome function.

Columbia University
Postdoctoral training - Developmental Neurobiology
2016

European Molecular Biology Laboratory (EMBL)
Ph.D. - Developmental Biology
2009

A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life.
Feng W, Li Y, Dao P, Aburas J, Islam P, Elbaz B, Kolarzyk A, Brown AE, Kratsios P. A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life. Elife. 2020 Jan 03; 9.
PMID: 31902393

Transcriptional mechanisms of motor neuron development in vertebrates and invertebrates.
Catela C, Kratsios P. Transcriptional mechanisms of motor neuron development in vertebrates and invertebrates. Dev Biol. 2019 Aug 31.
PMID: 31479648

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.
Catela C, Correa E, Wen K, Aburas J, Croci L, Consalez GG, Kratsios P. An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 01 18; 14(1):2.
PMID: 30658714

Neuronal identity control by terminal selectors in worms, flies, and chordates.
Hobert O, Kratsios P. Neuronal identity control by terminal selectors in worms, flies, and chordates. Curr Opin Neurobiol. 2019 06; 56:97-105.
PMID: 30665084

Nervous System Development: Flies and Worms Converging on Neuron Identity Control.
Kratsios P, Hobert O. Nervous System Development: Flies and Worms Converging on Neuron Identity Control. Curr Biol. 2018 10 08; 28(19):R1154-R1157.
PMID: 30300603

An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons.
Kratsios P, Kerk SY, Catela C, Liang J, Vidal B, Bayer EA, Feng W, De La Cruz ED, Croci L, Consalez GG, Mizumoto K, Hobert O. An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons. Elife. 2017 07 05; 6.
PMID: 28677525

Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression.
Kerk SY, Kratsios P, Hart M, Mourao R, Hobert O. Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression. Neuron. 2017 Jan 04; 93(1):80-98.
PMID: 28056346

A cellular and regulatory map of the cholinergic nervous system of C. elegans.
Pereira L, Kratsios P, Serrano-Saiz E, Sheftel H, Mayo AE, Hall DH, White JG, LeBoeuf B, Garcia LR, Alon U, Hobert O. A cellular and regulatory map of the cholinergic nervous system of C. elegans. Elife. 2015 Dec 25; 4.
PMID: 26705699

Transcriptional coordination of synaptogenesis and neurotransmitter signaling.
Kratsios P, Pinan-Lucarré B, Kerk SY, Weinreb A, Bessereau JL, Hobert O. Transcriptional coordination of synaptogenesis and neurotransmitter signaling. Curr Biol. 2015 May 18; 25(10):1282-95.
PMID: 25913400

Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene.
Kratsios P, Stolfi A, Levine M, Hobert O. Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene. Nat Neurosci. 2011 Nov 27; 15(2):205-14.
PMID: 22119902

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Award for Basic Research in Neurobiology
Whitehall Foundation
2017 - 2019

K99/R00 Pathway to Independence Award
National Institute of Health
2013 - 2018