David Freedman, PhD

Computational Cognitive and Visual Neuroscience



Through experience, we learn to interpret the sights and sounds around us and to make decisions that move us closer to achieving our goals. Our ability to learn from and adapt to our ever changing environment is a foundation of complex behavior, as it allows us to make sense of incoming sensory stimuli and to plan successful actions. To study these questions, our laboratory uses advanced neurophysiological and behavioral techniques, in parallel with machine learning approaches for studying cognitive computations in artificial neural networks. Together, our work is providing insights into the brain mechanisms of visual learning, recognition and decision making.

Harvard Medical School
Boston, MA
Postdoctoral - Neurobiology
2008

M.I.T.
Cambridge, MA
Ph.D. - Systems Neuroscience
2002

Posterior parietal cortex plays a causal role in perceptual and categorical decisions.
Zhou Y, Freedman DJ. Posterior parietal cortex plays a causal role in perceptual and categorical decisions. Science. 2019 07 12; 365(6449):180-185.
PMID: 31296771

Circuit mechanisms for the maintenance and manipulation of information in working memory.
Masse NY, Yang GR, Song HF, Wang XJ, Freedman DJ. Circuit mechanisms for the maintenance and manipulation of information in working memory. Nat Neurosci. 2019 07; 22(7):1159-1167.
PMID: 31182866

Alleviating catastrophic forgetting using context-dependent gating and synaptic stabilization.
Masse NY, Grant GD, Freedman DJ. Alleviating catastrophic forgetting using context-dependent gating and synaptic stabilization. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):E10467-E10475.
PMID: 30315147

An Integrative Framework for Sensory, Motor, and Cognitive Functions of the Posterior Parietal Cortex.
Freedman DJ, Ibos G. An Integrative Framework for Sensory, Motor, and Cognitive Functions of the Posterior Parietal Cortex. Neuron. 2018 03 21; 97(6):1219-1234.
PMID: 29566792

Mnemonic Encoding and Cortical Organization in Parietal and Prefrontal Cortices.
Masse NY, Hodnefield JM, Freedman DJ. Mnemonic Encoding and Cortical Organization in Parietal and Prefrontal Cortices. J Neurosci. 2017 06 21; 37(25):6098-6112.
PMID: 28539423

Sequential sensory and decision processing in posterior parietal cortex.
Ibos G, Freedman DJ. Sequential sensory and decision processing in posterior parietal cortex. Elife. 2017 04 24; 6.
PMID: 28418332

Computing by Robust Transience: How the Fronto-Parietal Network Performs Sequential, Category-Based Decisions.
Chaisangmongkon W, Swaminathan SK, Freedman DJ, Wang XJ. Computing by Robust Transience: How the Fronto-Parietal Network Performs Sequential, Category-Based Decisions. Neuron. 2017 Mar 22; 93(6):1504-1517.e4.
PMID: 28334612

Where Are Perceptual Decisions Made in the Brain?
Pesaran B, Freedman DJ. Where Are Perceptual Decisions Made in the Brain? Trends Neurosci. 2016 10; 39(10):642-644.
PMID: 27623195

Interaction between Spatial and Feature Attention in Posterior Parietal Cortex.
Ibos G, Freedman DJ. Interaction between Spatial and Feature Attention in Posterior Parietal Cortex. Neuron. 2016 Aug 17; 91(4):931-943.
PMID: 27499082

Maternal T. gondii, offspring bipolar disorder and neurocognition.
Freedman D, Bao Y, Shen L, Schaefer CA, Brown AS. Maternal T. gondii, offspring bipolar disorder and neurocognition. Psychiatry Res. 2016 Sep 30; 243:382-9.
PMID: 27449007

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