Ph.D. Cold Spring Harbor Laboratory
Department of Neurobiology
The University of Chicago
947 E. 58th St., MC0928
Chicago, IL 60637
Phone: (773) 702-2016 (office)/(773) 702-1501 (lab)
Fax: (773) 702-3774
Wei Lab website
Strategies for circuit assembly and development in the visual system.
How are neural circuits assembled during development to perform specific computations? An excellent model system to address this question is the retina, where a diverse set of neural circuits are wired with remarkable precision and intricacy to extract salient features such as color, contrast and motion from the visual scene. Each retinal circuit utilizes distinct neuronal types and conveys the processed visual information to higher brain by a specific type of retinal ganglion cells.
We are interested in the synaptic basis of neural computation in the retina. Our current research is focused on understanding the developmental and adult patterns of synaptic connections underlying the retinal circuits, and determining how the specific wiring patterns impact visual processing. We leverage the increasing repertoire of genetic tools that label specific retinal neuron types to target the synapses of interest, and characterize the maturation and function of these synapses using a combination of techniques including multiphoton microscopy, visual stimulation, electrophysiology and molecular biology. These studies will provide insight into the neural mechanisms of visual processing in the retina, and also have broader implications in the fundamental questions of synapse development and organization in the central nervous system.
Jason W Triplett, Wei Wei, Cristina Gonzalez, Neal T Sweeney, Andrew D Huberman, Marla B Feller and David A Feldheim .2014 “Dendritic and Axonal Targeting Patterns of a Genetically-Specified Class of Retinal Ganglion Cells that Participate in Image-Forming Circuits.” Neural Development 2014 Feb 5;9:2. doi: 10.1186/1749-8104-9-2.
Michal Rivlin-Etzion, Wei Wei and Marla Feller. 2012 “Visual stimulation reverses the directional preference of direction selective retinal ganglion cells.” Neuron 76, 518-525
Wei Wei and Marla B. Feller. 2011 “Organization and development of direction selective circuits in the retina” (Review). Trends in Neurosciences Dec;34(12):638-45. Epub 2011 Aug 26.
Michal Rivlin-Etzion, Kaili Zhou, Wei Wei, Justin Elstrott, Phong Nguyen, Ben Barres, Andrew Huberman, and Marla Feller. 2011 “Transgenic mice reveal unexpected diversity of On-Off direction selective retinal ganglion cell subtypes and brain structures involved in motion processing.” J. Neurosci. Jun 15; 31(24):8760-9.
Wei Wei, Aaron M. Hamby, Kaili Zhou, Marla B. Feller. 2011. “Development of asymmetric inhibition underlying retinal direction selectivity in the retina.” Nature 469(7330):402-6.
Wei Wei, Justin Elstrott, & Marla B. Feller. 2010. “Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina.” Nature Protocols 5, 1347– 1352.
Peter G. Fuerst, Freyja Bruce, Miao Tian, Wei Wei, Justin Elstrott, Marla B. Feller, Lynda Erskine, Joshua H. Singer, and Robert W. Burgess. 2009. “DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina.” Neuron 64(4):484-97.
Huberman A*, Wei W*, Elstrott J*, Stafford B, Feller MB, Barres B. 2009. “Genetic identification of On-Off direction selective retinal ganglion cells reveals a layer specific subcortical map of posterior motion.” Neuron 62: 327-334. (* equal contribution).
Wei Wei, Louis N. Nguyen, Helmut W. Kessels, Hiroaki Hagiwara, Sangram Sisodia and Roberto Malinow. 2009. “Amyloid-Beta from Dendrites and Axons Reduces Local Spine Number and Plasticity.” Nature Neuroscience 13, 190 – 196.
Kopec CD, Li B, Wei W, Boehm J, Malinow R. 2006. “Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation.” J. Neurosci. Feb 15;26(7):2000-9.
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